What Is Src?

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Cellular communication is a complex dance of molecular interactions, where various proteins and enzymes play pivotal roles in regulating a wide range of cellular processes. One such crucial player in the world of cellular signaling is Src, a proto-oncogene protein. In this blog post, we will explore what Src is, its functions, and its significance in both normal cell physiology and disease.

What Is Src?

Src is a family of non-receptor protein tyrosine kinases, a class of enzymes that play a central role in cellular signaling. It was first discovered as a transforming gene in the Rous sarcoma virus, a cancer-causing virus found in chickens. This discovery led to significant advancements in understanding cellular signaling pathways and their role in cancer.

Functions Of Src:

  1. Cellular Signaling: Src is involved in the regulation of multiple signaling pathways within cells. It acts as a molecular switch, transmitting signals from the cell membrane to the nucleus, ultimately influencing processes such as cell growth, differentiation, and survival.
  2. Cytoskeleton Regulation: Src plays a critical role in the control of the cytoskeleton, which is responsible for cell shape, movement, and adhesion. It phosphorylates key proteins involved in cytoskeletal dynamics, influencing cell motility and migration.
  3. Cell Adhesion: Src regulates cell adhesion by modulating the activity of adhesion molecules and integrins. This is essential for processes like wound healing, tissue remodeling, and immune cell function.
  4. Growth and Survival: Src is implicated in cell proliferation and survival. Dysregulation of Src can lead to uncontrolled cell growth, a hallmark of cancer.

Significance In Disease:

  1. Cancer: Src has been extensively studied in the context of cancer. It is considered an oncogene, as its abnormal activation can lead to uncontrolled cell growth and tumor formation. Inhibiting Src has been explored as a potential therapeutic strategy in various cancer types.
  2. Osteoporosis: Src is also implicated in bone metabolism. Inhibition of Src has been investigated as a treatment for conditions like osteoporosis, where excessive bone resorption contributes to bone loss.
  3. Neurodegenerative Diseases: Emerging research suggests that Src may have a role in neurodegenerative diseases like Alzheimer’s disease, though further study is needed to understand its precise mechanisms.

Clinical Applications:

Given its central role in cellular signaling and its association with diseases like cancer, Src has been a target for drug development. There are several Src inhibitors, such as Dasatinib and Bosutinib, approved for the treatment of specific cancer types. These drugs work by blocking Src’s kinase activity, which can help slow down the progression of cancer and improve patient outcomes.


Src is a pivotal protein in cellular signaling, influencing a wide array of cellular processes, from growth and survival to cytoskeletal dynamics and cell adhesion. Its discovery in the context of cancer has led to significant advances in our understanding of oncogenes and their role in disease. The development of Src inhibitors as therapeutic agents underscores its importance in clinical applications. As research continues to unravel the complexities of cellular signaling, Src remains a key player with immense potential for both basic science and clinical interventions.

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What Does Src Mean?

Science Research Council: a former agency responsible for scientific research that was publicly funded. Also known as the SERC or Science and Engineering Research Council.

What Is Src In Medical Terms?

Scleroderma renal crisis (SRC) is a life-threatening complication that can infrequently affect people who have systemic sclerosis (SSc), a multi-system autoimmune disease that affects the skin and other organs. It is thought to occur in about 10 percent of all patients with scleroderma.

What Is The Src Command In Html?

The required src attribute specifies the URL of the image. There are two ways to specify the URL in the src attribute: 1. Absolute URL – Links to an external image that is hosted on another website.

What Does Src Mean Java?

Describes the Java™ source tree. When you create an API project, it is set up as a Java project with separate folders for source and class files. The source folder is named src .

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